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Inside Back Cover: Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation (Angew. Chem. Int. Ed. 50/2019)
Author(s) -
Yuan Chengqian,
Levin Aviad,
Chen Wei,
Xing Ruirui,
Zou Qianli,
Herling Therese W.,
Challa Pavan Kumar,
Knowles Tuomas P. J.,
Yan Xuehai
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201913848
Subject(s) - nucleation , supramolecular chemistry , phase (matter) , enthalpy , amphiphile , chemistry , polymer , chemical engineering , supramolecular polymers , amino acid , crystallography , peptide , materials science , polymer chemistry , organic chemistry , thermodynamics , biochemistry , physics , engineering , copolymer , crystal structure
The separation of the liquid phase into solute‐rich and solute‐poor phases is an elementary step leading to the nucleation of supramolecular nanofibrils from amphiphilic amino acids and peptides. As X. Yan, T. P. J. Knowles et al. show in their Research Article on page 18116 ff., the solute‐rich liquid droplets with low enthalpy act as nucleation sites, significantly decrease the nucleation barrier towards solid phase, and eventually form thermodynamically more favorable nanofibrils.