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Enantioselective Synthesis of 3‐Substituted Cyclobutenes by Catalytic Conjugate Addition/Trapping Strategies
Author(s) -
Zhong Changxu,
Huang Yingchao,
Zhang Haocheng,
Zhou Qiang,
Liu Yu,
Lu Ping
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201913825
Subject(s) - enantioselective synthesis , conjugate , trapping , catalysis , chemistry , combinatorial chemistry , computer science , mathematics , biology , organic chemistry , mathematical analysis , ecology
A copper‐catalyzed tandem process to generate chiral cyclobutene derivatives has been developed. It is based on an enantioselective conjugate addition or reduction of a cyclobutenone and sequential trapping with a chlorophosphate in a one‐pot process. These phosphates are stable under mildly acidic conditions and serve as good electrophiles in Negishi coupling reactions.