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Inside Cover: Exploring the Trans‐Cleavage Activity of CRISPR‐Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor (Angew. Chem. Int. Ed. 48/2019)
Author(s) -
Dai Yifan,
Somoza Rodrigo A,
Wang Liu,
Welter Jean F.,
Li Yan,
Caplan Arnold I,
Liu Chung Chiun
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201913617
Subject(s) - crispr , biosensor , electrochemistry , chemistry , cleavage (geology) , nanotechnology , cover (algebra) , combinatorial chemistry , materials science , electrode , biochemistry , gene , engineering , mechanical engineering , fracture (geology) , composite material
An electrochemical biosensor based on CRISPR‐Cas12a (cpf1), termed E‐CRISPR, is reported by Y. Dai, A. I. Caplan, C. C. Liu et al. in their Research Article on page 17399 ff. The recognition and the following cleavage activities of CRISPR‐Cas12a make CRISPR itself an integrated sensing and actuating system. Transducing the CRISPR activity through electrochemistry delivers an electrochemical biosensor for the detection of nucleic acids and proteins.