Enantioselective Difunctionalization of Alkenes by a Palladium‐Catalyzed Heck/Sonogashira Sequence | Zendy

Zhou Lujia | Zendy; Li Sanliang | Zendy; Xu Bing | Zendy; Ji Danting | Zendy; Wu Lizuo | Zendy; Liu Yu | Zendy; Zhang ZhanMing | Zendy; Zhang Junliang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Enantioselective Difunctionalization of Alkenes by a Palladium‐Catalyzed Heck/Sonogashira Sequence

Author(s) -

Zhou Lujia,

Li Sanliang,

Xu Bing,

Ji Danting,

Wu Lizuo,

Liu Yu,

Zhang ZhanMing,

Zhang Junliang

Publication year - 2020

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201913367

Subject(s) - stereocenter , sonogashira coupling , palladium , enantioselective synthesis , chemistry , combinatorial chemistry , intramolecular force , catalysis , propargyl , sequence (biology) , organic chemistry , biochemistry

Sonogashira‐type cross‐couplings are one of the most significant alkynylations in organic chemistry. One of the first palladium‐catalyzed intramolecular Heck/Sonogashira reactions of alkenes with terminal alkynes is now reported. With this method, a variety of uniquely substituted chiral benzene‐fused heterocycles bearing a propargyl‐substituted all‐carbon quaternary stereocenter were obtained in a straightforward, high‐yielding, and highly stereoselective manner under mild conditions. Salient features of this process include the use of readily available substrates, high selectivities, a broad substrate scope as well as versatile product functionalizations.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research