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Nickel(0)‐Catalyzed Enantioselective [3+2] Annulation of Cyclopropenones and α,β‐Unsaturated Ketones/Imines
Author(s) -
Bai Dachang,
Yu Yanjiang,
Guo Haiming,
Chang Junbiao,
Li Xingwei
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201913130
Subject(s) - enantioselective synthesis , annulation , cycloaddition , chemistry , imine , catalysis , intermolecular force , cleavage (geology) , nickel , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , molecule , geotechnical engineering , fracture (geology) , engineering
Ni 0 ‐catalyzed chemo‐ and enantioselective [3+2] cycloaddition of cyclopropenones and α,β‐unsaturated ketones/imines is described. This reaction integrates C−C bond cleavage of cyclopropenones and enantioselective functionalization by carbonyl/imine group, offering a mild approach to γ‐alkenyl butenolides and lactams in excellent enantioselectivity (88–98 % ee ) through intermolecular C−C activation.