Nickel(0)‐Catalyzed Enantioselective [3+2] Annulation of Cyclopropenones and α,β‐Unsaturated Ketones/Imines | Zendy

Bai Dachang | Zendy; Yu Yanjiang | Zendy; Guo Haiming | Zendy; Chang Junbiao | Zendy; Li Xingwei | Zendy

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Nickel(0)‐Catalyzed Enantioselective [3+2] Annulation of Cyclopropenones and α,β‐Unsaturated Ketones/Imines

Author(s) -

Bai Dachang,

Yu Yanjiang,

Guo Haiming,

Chang Junbiao,

Li Xingwei

Publication year - 2020

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201913130

Subject(s) - enantioselective synthesis , annulation , cycloaddition , chemistry , imine , catalysis , intermolecular force , cleavage (geology) , nickel , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , molecule , geotechnical engineering , fracture (geology) , engineering

Ni 0 ‐catalyzed chemo‐ and enantioselective [3+2] cycloaddition of cyclopropenones and α,β‐unsaturated ketones/imines is described. This reaction integrates C−C bond cleavage of cyclopropenones and enantioselective functionalization by carbonyl/imine group, offering a mild approach to γ‐alkenyl butenolides and lactams in excellent enantioselectivity (88–98 % ee ) through intermolecular C−C activation.

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