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To Sandwich Technetium: Highly Functionalized Bis‐Arene Complexes [ 99m Tc(η 6 ‐arene) 2 ] + Directly from Water and [ 99m TcO 4 ] −
Author(s) -
Nadeem Qaisar,
Meola Giuseppe,
Braband Henrik,
Bolliger Robin,
Blacque Olivier,
HernándezValdés Daniel,
Alberto Roger
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201912994
Subject(s) - rhenium , group 2 organometallic chemistry , chemistry , denticity , molecule , technetium , metal , stereochemistry , crystallography , nuclear chemistry , organic chemistry
The labeling of (bio)molecules with metallic radionuclides such as 99m Tc demands conjugated, multidentate chelators. However, this is not always necessary since phenyl rings can directly serve as integrated, organometallic ligands. Bis‐arene sandwich complexes are generally prepared by the Fischer–Hafner reaction. In extension of this, we show that [ 99m Tc(η 6 ‐C 6 R 6 ) 2 ] + ‐type complexes are directly accessible from water and [ 99m TcO 4 ] − , even using arenes incompatible with Fischer–Hafner conditions. To unambiguously confirm the nature of these unprecedented 99m Tc complexes, their rhenium homologous have been prepared by substituting naphthalene ligands in [Re(η 6 ‐C 10 H 8 ) 2 ] + with the corresponding phenyl groups. The ease with which highly stable [ 99m Tc(η 6 ‐C 6 R 6 ) 2 ] + complexes are formed under standard labeling conditions enables a multitude of new potential imaging agents based on commercial pharmaceuticals or lead structures.