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Photosynthetic Tumor Oxygenation by Photosensitizer‐Containing Cyanobacteria for Enhanced Photodynamic Therapy
Author(s) -
Huo Minfeng,
Wang Liying,
Zhang Linlin,
Wei Chenyang,
Chen Yu,
Shi Jianlin
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201912824
Subject(s) - photosensitizer , photodynamic therapy , singlet oxygen , cyanobacteria , photosynthesis , chlorin , chemistry , reactive oxygen species , in vivo , photochemistry , nanomedicine , biophysics , cancer research , oxygen , materials science , medicine , nanotechnology , nanoparticle , biochemistry , biology , bacteria , microbiology and biotechnology , organic chemistry , genetics
Sustained tumor oxygenation is of critical importance during type‐II photodynamic therapy (PDT), which depends on the intratumoral oxygen level for the generation of reactive oxygen species. Herein, the modification of photosynthetic cyanobacteria with the photosensitizer chlorin e6 (ce6) to form ce6‐integrated photosensitive cells, termed ceCyan, is reported. Upon 660 nm laser irradiation, sustained photosynthetic O 2 evolution by the cyanobacteria and the immediate generation of reactive singlet oxygen species ( 1 O 2 ) by the integrated photosensitizer could be almost simultaneously achieved for tumor therapy using type‐II PDT both in vitro and in vivo. This work contributes a conceptual while practical paradigm for biocompatible and effective PDT using hybrid microorganisms, displaying a bright future in clinical PDT by microbiotic nanomedicine.