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Parallel Homochiral and Anti‐Parallel Heterochiral Hydrogen‐Bonding Interfaces in Multi‐Helical Abiotic Foldamers
Author(s) -
Mazzier Daniela,
De Soumen,
Wicher Barbara,
Maurizot Victor,
Huc Ivan
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201912805
Subject(s) - chemistry , hydrogen bond , helix (gastropod) , crystallography , folding (dsp implementation) , protein folding , stereochemistry , molecule , organic chemistry , ecology , biochemistry , snail , electrical engineering , biology , engineering
A hydrogen‐bonding interface between helical aromatic oligoamide foldamers has been designed to promote the folding of a helix‐turn‐helix motif with a head‐to‐tail arrangement of two helices of opposite handedness. This design complements an earlier helix‐turn‐helix motif with a head‐to‐head arrangement of two helices of identical handedness interface. The two motifs were shown to have comparable stability and were combined in a unimolecular tetra‐helix fold constituting the largest abiotic tertiary structure to date.