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A Supramolecular Trap to Increase the Antibacterial Activity of Colistin
Author(s) -
Liao FangHsuean,
Wu TeHaw,
Yao ChunNien,
Kuo ShuChen,
Su ChunJen,
Jeng USer,
Lin ShuYi
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201912137
Subject(s) - colistin , polymyxin , lipid a , lipopolysaccharide , polymyxin b , antibiotics , antibacterial activity , chemistry , microbiology and biotechnology , bacteria , biology , immunology , genetics
A strong interaction between colistin, a last‐resort antibiotic of the polymyxin family, and free lipopolysaccharide (LPS, also referred to as endotoxin), released from the Gram‐negative bacterial (GNB) outer membrane (OM), has been identified that can decrease the antibacterial efficacy of colistin, potentially increasing the dose of this antibiotic required for treatment. The competition between LPS in the GNB OM and free LPS for the interaction with colistin was prevented by using a supramolecular trap to capture free LPS. The supramolecular trap, fabricated from a subnanometer gold nanosheet with methyl motifs (SAuM), blocks lipid A, preventing the interaction between lipid A and colistin. This can minimize endotoxemia and maximize the antibacterial efficacy of colistin, enabling colistin to be used at lower doses. Thus, the potential crisis of colistin resistance could be avoided.