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Chiral N‐Heterocyclic Carbene Ligands Enable Asymmetric C−H Bond Functionalization
Author(s) -
Thongpaen Jompol,
Manguin Romane,
Baslé Olivier
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201911898
Subject(s) - carbene , enantioselective synthesis , surface modification , chemistry , catalysis , combinatorial chemistry , organocatalysis , organic synthesis , organic chemistry , stereochemistry
The asymmetric functionalization of C−H bond is a particularly valuable approach for the production of enantioenriched chiral organic compounds. Chiral N‐heterocyclic carbene (NHC) ligands have become ubiquitous in enantioselective transition‐metal catalysis. Conversely, the use of chiral NHC ligands in metal‐catalyzed asymmetric C−H bond functionalization is still at an early stage. This minireview highlights all the developments and the new advances in this rapidly evolving research area.