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An Activatable NIR‐II Nanoprobe for In Vivo Early Real‐Time Diagnosis of Traumatic Brain Injury
Author(s) -
Li Chunyan,
Li Wanfei,
Liu Huanhuan,
Zhang Yejun,
Chen Guangcun,
Li Zijing,
Wang Qiangbin
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201911803
Subject(s) - nanoprobe , in vivo , peroxynitrite , fluorescence , traumatic brain injury , biomarker , medicine , pathology , biophysics , materials science , chemistry , nanotechnology , biology , biochemistry , optics , nanoparticle , microbiology and biotechnology , psychiatry , physics , enzyme , superoxide
Traumatic brain injury (TBI) is one of the most dangerous acute diseases resulting in high morbidity and mortality. Current methods remain limited with respect to early diagnosis and real‐time feedback on the pathological process. Herein, a targeted activatable fluorescent nanoprobe (V&A@Ag 2 S) in the second near‐infrared window (NIR‐II) is presented for in vivo optical imaging of TBI. Initially, the fluorescence of V&A@Ag 2 S is turned off owing to energy transfer from Ag 2 S to the A1094 chromophore. Upon intravenous injection, V&A@Ag 2 S quickly accumulates in the inflamed vascular endothelium of TBI based on VCAM1‐mediated endocytosis, after which the nanoprobe achieves rapid recovery of the NIR‐II fluorescence of Ag 2 S quantum dots (QDs) owing to the bleaching of A1094 by the prodromal biomarker of TBI, peroxynitrite (ONOO − ). The nanoprobe offers high specificity, rapid response, and high sensitivity toward ONOO − , providing a convenient approach for in vivo early real‐time assessment of TBI.