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Cover Picture: Voltage‐Switchable HCl Transport Enabled by Lipid Headgroup–Transporter Interactions (Angew. Chem. Int. Ed. 42/2019)
Author(s) -
Wu Xin,
Small Jennifer R.,
Cataldo Alessio,
Withecombe Anne M.,
Turner Peter,
Gale Philip A.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201911407
Subject(s) - symporter , transporter , chemistry , transmembrane protein , lipid bilayer , ion transporter , transmembrane domain , ion , membrane , ion channel , biophysics , stereochemistry , biochemistry , biology , organic chemistry , receptor , gene
A tetraurea macrocycle and other synthetic anion transporters facilitate transmembrane H + /Cl − symport and show attenuated transport rates in the presence of a membrane potential, as described by P. A. Gale et al. in their Research Article on page 15142 ff. This voltage‐dependent property, reminiscent of voltage‐gated ion channels, is related to the binding of anion transporters to lipid phosphate headgroups that inhibits the transmembrane diffusion of anion transporters.