Synthesis of All‐Carbon Quaternary Centers by Palladium‐Catalyzed Olefin Dicarbofunctionalization | Zendy

Koy Maximilian | Zendy; Bellotti Peter | Zendy; Katzenburg Felix | Zendy; Daniliuc Constantin G. | Zendy; Glorius Frank | Zendy

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Synthesis of All‐Carbon Quaternary Centers by Palladium‐Catalyzed Olefin Dicarbofunctionalization

Author(s) -

Koy Maximilian,

Bellotti Peter,

Katzenburg Felix,

Daniliuc Constantin G.,

Glorius Frank

Publication year - 2020

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201911012

Subject(s) - oxindole , palladium , catalysis , olefin fiber , quaternary carbon , chemistry , alkyl , aryl , carbon fibers , cascade , organic chemistry , combinatorial chemistry , enantioselective synthesis , materials science , composite number , composite material , chromatography

The redox‐neutral dicarbofunctionalization of tri‐ and tetrasubstituted olefins to form a variety of (hetero)cyclic compounds under photoinduced palladium catalysis is described. This cascade reaction process was used to couple styrenes or acryl amides with a broad range of highly decorated olefins tethered to aryl or alkyl bromides (>50 examples). This procedure enables one or two contiguous all‐carbon quaternary centers to be formed in a single step. The products could be readily diversified and applied in the synthesis of a bioactive oxindole analogue.

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