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Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels
Author(s) -
Yuan Hongbo,
Zhan Yong,
Rowan Alan E.,
Xing Chengfen,
Kouwer Paul H. J.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201910979
Subject(s) - polythiophene , conjugated system , ethylene glycol , self healing hydrogels , thiophene , photochemistry , polymer , materials science , antimicrobial , chemistry , polymer chemistry , organic chemistry , conductive polymer
Hybrid biomimetic hydrogels with enhanced reactive oxygen species (ROS)‐generation efficiency under 600 nm light show high antibacterial activity. The hybrid gels are composed of helical tri(ethylene glycol)‐functionalized polyisocyanides (PICs) and a conformation‐sensitive conjugated polythiophene, poly(3‐(3′‐ N , N , N ‐triethylammonium‐1′‐propyloxy)‐4‐methyl‐2,5‐thiophene chloride) (PMNT). The PIC polymer serves as a scaffold to trap and align the PMNT backbone into a highly ordered conformation, resulting in redshifted, new sharp bands in the absorption and fluorescence spectra. Similar to PIC, the hybrid closely mimics the mechanical properties of biological gels, such as collagen and fibrin, including the strain stiffening properties at low stresses. Moreover, the PMNT/PIC hybrids show much higher ROS production efficiency under red light than PMNT only, leading to an efficient photodynamic antimicrobial effect towards various pathogenic bacteria.