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Enantioselective Desymmetrization of Cyclobutanones: A Speedway to Molecular Complexity
Author(s) -
Sietmann Jan,
Wahl Johannes M.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201910767
Subject(s) - desymmetrization , enantioselective synthesis , variety (cybernetics) , chemistry , stereochemistry , computer science , organic chemistry , catalysis , artificial intelligence
Cyclobutanones hold a privileged role in enantioselective desymmetrization because their inherent ring strain allows for a variety of unusual reactions to occur. Current strategies include α‐functionalization, rearrangement, and C−C bond activation to directly convert cyclobutanones into a wide range of enantiomerically enriched compounds, including many biologically significant scaffolds. This Minireview provides an overview of state‐of‐the‐art methods that generate complexity from prochiral cyclobutanones in a single operation.