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Designed Negative Feedback from Transiently Formed Catalytic Nanostructures
Author(s) -
Afrose Syed Pavel,
Bal Subhajit,
Chatterjee Ayan,
Das Krishnendu,
Das Dibyendu
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201910280
Subject(s) - substrate (aquarium) , catalysis , polymerization , nanostructure , chemistry , hydrolysis , realization (probability) , chemical physics , materials science , nanotechnology , chemical engineering , organic chemistry , oceanography , engineering , geology , polymer , statistics , mathematics
Highly dynamic and complex systems of microtubules undergo a substrate‐induced change of conformation that leads to polymerization. Owing to the augmented catalytic potential at the polymerized state, rapid hydrolysis of the substrate is observed, leading to catastrophe, thus realizing the out‐of‐equilibrium state. A simple synthetic mimic of these dynamic natural systems is presented, where similar substrate induced conformational change is observed and a transient helical morphology is accessed. Further, augmented catalytic potential of these helical nanostructures leads to rapid hydrolysis of the substrate providing negative feedback on the stability of the nanostructures and realization of an out‐of‐equilibrium state. This simple system, made from amino acid functionalized lipids, demonstrates a substrate‐induced self‐assembled state, where the fuel‐to‐waste conversion leads to the temporal presence of helical nanostructures.