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A Supramolecular Radical Dimer: High‐Efficiency NIR‐II Photothermal Conversion and Therapy
Author(s) -
Tang Bohan,
Li WanLu,
Chang Yincheng,
Yuan Bin,
Wu Yukun,
Zhang MingTian,
Xu JiangFei,
Li Jun,
Zhang Xi
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201910257
Subject(s) - photothermal therapy , supramolecular chemistry , dimer , luminescence , chromophore , radical , photochemistry , thiazole , materials science , chemistry , nanotechnology , optoelectronics , organic chemistry , molecule
Photothermal therapy at the NIR‐II biowindow (1000–1350 nm) is drawing increasing interest because of its large penetration depth and maximum permissible exposure. Now, the supramolecular radical dimer, fabricated by N,N′‐dimethylated dipyridinium thiazolo[5,4‐d]thiazole radical cation (MPT .+ ) and cucurbit[8]uril (CB[8]), achieves strong absorption at NIR‐II biowindow. The supramolecular radical dimer (2MPT .+ ‐CB[8]) showed highly efficient photothermal conversion and improved stability, thus contributing to the strong inhibition on HegG2 cancer cell under 1064 nm irradiation even penetrating through chicken breast tissue. This work provides a novel approach to construct NIR‐II chromophore by tailor‐made assembly of organic radicals. It is anticipated that this study provides a new strategy to achieve NIR‐II photothermal therapy and holds promises in luminescence materials, optoelectronic materials, and also biosensing.