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Inside Back Cover: Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria (Angew. Chem. Int. Ed. 37/2019)
Author(s) -
Çapcı Aysun,
Lorion Mélanie M.,
Wang Hui,
Simon Nina,
Leidenberger Maria,
Borges Silva Mariana C.,
Moreira Diogo R. M.,
Zhu Yongping,
Meng Yuqing,
Chen Jia Yun,
Lee Yew Mun,
Friedrich Oliver,
Kappes Barbara,
Wang Jigang,
Ackermann Lutz,
Tsogoeva Svetlana B.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201910149
Subject(s) - pharmacophore , artemisinin , multiple drug resistance , malaria , chemistry , drug resistance , plasmodium falciparum , click chemistry , biology , combinatorial chemistry , stereochemistry , microbiology and biotechnology , immunology
Overcoming drug resistance in malaria parasites against available drugs is possible by using drug hybrids, as reported by S. B. Tsogoeva, L. Ackermann, J. Wang, and co‐workers in their Research Article on page 13066 ff. The merging of two differently acting drugs (e.g., artemisinin and chloroquine) in one hybrid compound gives simultaneous cellular uptake of the pharmacophore components of the hybrid, and dual action is achieved, thereby enabling novel functions targeting pathogens, multidrug resistance.