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Visible‐Light‐Driven Janus Microvehicles in Biological Media
Author(s) -
Pacheco Marta,
JuradoSánchez Beatriz,
Escarpa Alberto
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201910053
Subject(s) - janus particles , biocompatibility , nanotechnology , janus , chemistry , biocompatible material , quantum dot , visible spectrum , hela , materials science , nanoparticle , optoelectronics , organic chemistry , medicine , biochemistry , biomedical engineering , cell
Abstract A light‐driven multifunctional Janus micromotor for the removal of bacterial endotoxins and heavy metals is described. The micromotor was assembled by using the biocompatible polymer polycaprolactone for the encapsulation of CdTe or CdSe@ZnS quantum dots (QDs) as photoactive materials and an asymmetric Fe 3 O 4 patch for propulsion. The micromotors can be activated with visible light (470–490 nm) to propel in peroxide or glucose media by a diffusiophoretic mechanism. Efficient propulsion was observed for the first time in complex samples such as human blood serum. These properties were exploited for efficient endotoxin removal using lipopolysaccharides from Escherichia coli O111:B4 as a model toxin. The micromotors were also used for mercury removal by cationic exchange with the CdSe@ZnS core–shell QDs. Cytotoxicity assays in HeLa cell lines demonstrated the high biocompatibility of the micromotors for future detoxification applications.