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A Novel DNA Helical Wire Containing Hg II ‐Mediated T:T and T:G Pairs
Author(s) -
Ono Akira,
Kanazawa Hiroki,
Ito Hikari,
Goto Misato,
Nakamura Koudai,
Saneyoshi Hisao,
Kondo Jiro
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201910029
Subject(s) - base pair , dna , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , oligonucleotide , crystallography , nucleic acid , base (topology) , crystal structure , metal , z dna , chemistry , stereochemistry , biochemistry , mathematical analysis , mathematics , organic chemistry
Numerous applications of metal‐mediated base pairs (metallo‐base‐pairs) to nucleic acid based nanodevices and genetic code expansion have been extensively studied. Many of these metallo‐base‐pairs are formed in DNA and RNA duplexes containing Watson–Crick base pairs. Recently, a crystal structure of a metal–DNA nanowire with an uninterrupted one‐dimensional silver array was reported. We now report the crystal structure of a novel DNA helical wire containing Hg II ‐mediated T:T and T:G base pairs and water‐mediated C:C base pairs. The Hg‐DNA wire does not contain any Watson–Crick base pairs. Crystals of the Hg‐DNA wire, which is the first DNA wire structure driven by Hg II ions, were obtained by mixing the short oligonucleotide d(TTTGC) and Hg II ions. This study demonstrates the potential of metallo‐DNA to form various structural components that can be used for functional nanodevices.