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Atroposelective Phosphoric Acid Catalyzed Three‐Component Cascade Reaction: Enantioselective Synthesis of Axially Chiral N‐Arylindoles
Author(s) -
Wang Lei,
Zhong Jialing,
Lin Xufeng
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201909855
Subject(s) - enantioselective synthesis , phosphoric acid , axial symmetry , cascade , catalysis , chemistry , combinatorial chemistry , component (thermodynamics) , organic chemistry , physics , chromatography , quantum mechanics , thermodynamics
An efficient organocatalytic atroposelective three‐component cascade reaction of 2,3‐diketoesters, aromatic amines, and 1,3‐cyclohexanediones has been developed for the highly enantioselective synthesis of axially chiral N‐arylindoles. The success of this method derives from the use of a newly developed second‐generation chiral spirocyclic phosphoric acid as the catalyst. In addition, this protocol was extended to the synthesis of an axially chiral monophosphorus ligand.