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Inside Cover: De novo Design of Selective Membrane‐Active Peptides by Enzymatic Control of Their Conformational Bias on the Cell Surface (Angew. Chem. Int. Ed. 39/2019)
Author(s) -
Shi Junfeng,
Schneider Joel P.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201909517
Subject(s) - peptide , folding (dsp implementation) , membrane , chemistry , biophysics , enzyme , cover (algebra) , lysis , cell membrane , cell , protein folding , biochemistry , biology , mechanical engineering , engineering , electrical engineering
A new class of peptide whose ability to perturb cellular membranes is coupled to an enzyme‐mediated shift in the folding potential of the peptide into a membrane‐active conformation is reported by J. Shi and J. Schneider in their Communication on page 13706 ff. Folding potential is cell specific and depends on the amount of cell‐surface alkaline phosphatase present. Once folded, the concentration of the peptide determines whether it enters or lyses cells.