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Retracted: Combined Photoredox/Enzymatic C−H Benzylic Hydroxylations
Author(s) -
Betori Rick C.,
May Catherine M.,
Scheidt Karl A.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201909426
Subject(s) - chemoselectivity , hydroxylation , photoredox catalysis , chemistry , heteroatom , reactivity (psychology) , combinatorial chemistry , enzyme , catalysis , biocatalysis , stereochemistry , organic chemistry , reaction mechanism , photocatalysis , ring (chemistry) , medicine , alternative medicine , pathology
Abstract Chemical transformations that install heteroatoms into C−H bonds are of significant interest because they streamline the construction of value‐added small molecules. Direct C−H oxyfunctionalization, or the one step conversion of a C−H bond to a C−O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single‐flask photoredox/enzymatic process for direct C−H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.