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Supported Catalytically Active Supramolecular Hydrogels for Continuous Flow Chemistry
Author(s) -
Rodon Fores Jennifer,
CriadoGonzalez Miryam,
Chaumont Alain,
Carvalho Alain,
Blanck Christian,
Schmutz Marc,
Serra Christophe A.,
Boulmedais F.,
Schaaf Pierre,
Jierry Loïc
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201909424
Subject(s) - supramolecular chemistry , self healing hydrogels , nanotechnology , kinetic resolution , chemistry , materials science , molecule , catalysis , polymer chemistry , organic chemistry , enantioselective synthesis
Inspired by biology, one current goal in supramolecular chemistry is to control the emergence of new functionalities arising from the self‐assembly of molecules. In particular, some peptides can self‐assemble and generate exceptionally catalytically active fibrous networks able to underpin hydrogels. Unfortunately, the mechanical fragility of these materials is incompatible with process developments, relaying this exciting field to academic curiosity. Here, we show that this drawback can be circumvented by enzyme‐assisted self‐assembly of peptides initiated at the walls of a supporting porous material. We applied this strategy to grow an esterase‐like catalytically active supramolecular hydrogel (CASH) in an open‐cell polymer foam, filling the whole interior space. Our supported CASH material is highly efficient towards inactivated esters and enables the kinetic resolution of racemates. This hybrid material is robust enough to be used in continuous flow reactors, and is reusable and stable over months.