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Cover Picture: Conditional Singlet Oxygen Generation through a Bioorthogonal DNA‐targeted Tetrazine Reaction (Angew. Chem. Int. Ed. 37/2019)
Author(s) -
Linden Greta,
Zhang Lei,
Pieck Fabian,
Linne Uwe,
Kosenkov Dmitri,
Tonner Ralf,
Vázquez Olalla
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201909198
Subject(s) - bioorthogonal chemistry , singlet oxygen , tetrazine , photodynamic therapy , cover (algebra) , chemistry , combinatorial chemistry , singlet state , photochemistry , oxygen , nanotechnology , materials science , physics , organic chemistry , engineering , click chemistry , atomic physics , mechanical engineering , excited state
Tetrazine can act as an effective singlet oxygen quencher of halogenated BODIPY photosensitizers. In their Communication on page 12868 ff., O. Vázquez and co‐workers report bioorthogonal, activatable probes that allow both organelle‐specific localization and conditional singlet oxygen production simultaneously. These compounds open new avenues to combat the current limitations of photodynamic therapy. Cover design: Prof. M. Eugenio Vázquez.