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Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy
Author(s) -
Zhang Liang,
Wang Shibo,
Zhou Yi,
Wang Chao,
Zhang XianZheng,
Deng Hexiang
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201909020
Subject(s) - covalent organic framework , covalent bond , photodynamic therapy , reactive oxygen species , terphenyl , biocompatibility , chemistry , oxygen , in vivo , molecule , photochemistry , organic chemistry , biochemistry , microbiology and biotechnology , biology
Covalent organic frameworks (COFs) with 2D π‐conjugation were designed and synthesized as molecular photosensitizers for efficient photodynamic therapy. Two molecules, 5′,5′′′′‐(1,4‐phenylene)bis(([1,1′:3′,1′′‐terphenyl]‐4,4′′‐dicarbaldehyde)) (L‐3C) and 4,4′,4′′‐(1,4‐phenylene)bis(([2,2′:6′,2′′‐terpyridine]‐5,5′′‐dicarbaldehyde)) (L‐3N), inactive to generating reactive oxygen species (ROS), were linked to form two COFs, COF‐808 and COF‐909, respectively, exhibiting excellent ROS production efficiency. The high permanent porosity of these COFs (surface areas 2270 and 2610 m 2 g −1 ) promoted diffusion of both oxygen and release of ROS in cells. This, combined with the excellent photostability and biocompatibility, led to excellent PDT performance. In vitro, over 80 % of tumor cells were killed after PDT treatment using COF‐909 at the concentration of 50 μg mL −1 for 150 s. In vivo, drastic reduction of tumor size was observed (from 9 mm to less than 1 mm) after 10 day treatment.