Enantioselective Iridium‐Catalyzed Allylation of Acetylenic Ketones via 2‐Propanol‐Mediated Reductive Coupling of Allyl Acetate: C14‐C23 of Pladienolide D | Zendy

Brito Gilmar A. | Zendy; Jung WooOk | Zendy; Yoo Minjin | Zendy; Krische Michael J. | Zendy

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Enantioselective Iridium‐Catalyzed Allylation of Acetylenic Ketones via 2‐Propanol‐Mediated Reductive Coupling of Allyl Acetate: C14‐C23 of Pladienolide D

Author(s) -

Brito Gilmar A.,

Jung WooOk,

Yoo Minjin,

Krische Michael J.

Publication year - 2019

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201908939

Subject(s) - enantioselective synthesis , catalysis , chemistry , iridium , ketone , organic chemistry , coupling (piping) , medicinal chemistry , combinatorial chemistry , materials science , metallurgy

Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14‐C23 of pladienolide D in half the steps previously required.

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