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Inside Cover: Molecular Bases for Anesthetic Agents: Halothane as a Halogen‐ and Hydrogen‐Bond Donor (Angew. Chem. Int. Ed. 36/2019)
Author(s) -
Nayak Susanta K.,
Terraneo Giancarlo,
Piacevoli Quirino,
Bertolotti Federica,
Scilabra Patrick,
Brown John T.,
Rosokha Sergiy V.,
Resnati Giuseppe
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201908842
Subject(s) - halothane , halogen bond , hydrogen bond , chemistry , anesthetic , halogen , solid state , hydrogen , polymer chemistry , combinatorial chemistry , molecule , organic chemistry , anesthesia , medicine , alkyl
Halothane, a commonly used anesthetic can simultaneously function as a hydrogen‐bond and a halogen‐bond donor in the solid state and in solution, as shown by S. V. Rosokha, G. Resnati, and co‐workers in their Communication on page 12456 ff. Both interactions involve moieties commonly present in cell membranes, probable target structures of halothane in the human body. The ability of the agent to act as a polydentate tecton gives a molecular rationale for its eudismic ratio.