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Inside Back Cover: Asymmetric Hydrocyanation of Alkenes without HCN (Angew. Chem. Int. Ed. 32/2019)
Author(s) -
Li Xiuxiu,
You Cai,
Yang Jiaxin,
Li Shuailong,
Zhang Dequan,
Lv Hui,
Zhang Xumu
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201908626
Subject(s) - hydrocyanation , chemistry , hydroformylation , nitrile , scope (computer science) , cover (algebra) , condensation , benzazepines , organic chemistry , medicinal chemistry , stereochemistry , catalysis , computer science , physics , rhodium , mechanical engineering , engineering , thermodynamics , programming language
An asymmetric cyanide‐free hydrocyanation of alkenes has been developed and described by H. Lv, X. Zhang and co‐workers in their Communication on page 10928 ff. Based on the asymmetric hydroformylation/condensation/aza‐Cope elimination sequences, a broad scope of substrates including mono‐substituted, 1,2‐ and 1,1‐disubstituted alkenes were employed, and a series of valuable chiral nitriles were prepared with high yields (up to 95%) and enantioselectivities (up to 98% ee).