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A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant Pt IV Prodrug Activation
Author(s) -
Norman Daniel J.,
Gambardella Alessia,
Mount Andrew R.,
Murray Alan F.,
Bradley Mark
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201908511
Subject(s) - singlet oxygen , prodrug , ruthenium , oxaliplatin , chemistry , catalysis , photocatalysis , photochemistry , oxygen , biochemistry , cancer , biology , organic chemistry , colorectal cancer , genetics
A ruthenium‐based mitochondrial‐targeting photosensitiser that undergoes efficient cell uptake, enables the rapid catalytic conversion of Pt IV prodrugs into their active Pt II counterparts, and drives the generation of singlet oxygen was designed. This dual mode of action drives two orthogonal cancer‐cell killing mechanisms with temporal and spatial control. The designed photosensitiser was shown to elicit cell death of a panel of cancer cell lines including those showing oxaliplatin‐resistance.