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Copper‐Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes
Author(s) -
Liu ZhengLi,
Yang Chao,
Xue QiYan,
Zhao Meng,
Shan CuiCui,
Xu YunHe,
Loh TeckPeng
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201908343
Subject(s) - propargyl , silylation , catalysis , chemistry , copper , reaction conditions , organic chemistry , combinatorial chemistry , medicinal chemistry
A copper‐catalyzed silylation of propargyl dichlorides was developed to access chloro‐substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro‐substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol.