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Back Cover: Transition‐Metal‐Free Hydrogen Autotransfer: Diastereoselective N‐Alkylation of Amines with Racemic Alcohols (Angew. Chem. Int. Ed. 31/2019)
Author(s) -
Xiao Miao,
Yue Xin,
Xu Ruirui,
Tang Weijun,
Xue Dong,
Li Chaoqun,
Lei Ming,
Xiao Jianliang,
Wang Chao
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201908296
Subject(s) - chemistry , alkylation , catalysis , transition metal , ketone , organic chemistry , hydrogen , combinatorial chemistry , medicinal chemistry
A practical method for the synthesis of α‐chiral amines that is based on the alkylation of amines with alcohols and does not require any transition‐metal catalysts is described by M. Lei, J. L. Xiao, C. Wang, and co‐workers in their Research Article on page 10528 ff. With a ketone and NaOH as co‐catalysts, racemic alcohols react with Ellman's chiral sulfinamide, affording chiral amines with high diastereoselectivities. This method also provides access to chiral deuterium‐labeled amines and drug molecules.