Back Cover: Total Synthesis of (−)‐Salinosporamide A via a Late Stage C−H Insertion (Angew. Chem. Int. Ed. 30/2019) | Zendy

Gholami Hadi | Zendy; Kulshrestha Aman | Zendy; Favor Olivia K. | Zendy; Staples Richard J. | Zendy; Borhan Babak | Zendy

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Back Cover: Total Synthesis of (−)‐Salinosporamide A via a Late Stage C−H Insertion (Angew. Chem. Int. Ed. 30/2019)

Author(s) -

Gholami Hadi,

Kulshrestha Aman,

Favor Olivia K.,

Staples Richard J.,

Borhan Babak

Publication year - 2019

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201907852

Subject(s) - intramolecular force , bromide , hydroamination , total synthesis , steric effects , insertion reaction , chemistry , carbene , cover (algebra) , stereochemistry , polymer chemistry , catalysis , organic chemistry , engineering , mechanical engineering

A total synthesis of (−)‐Salinosporamide A is presented by B. Borhan and co‐workers in their Communication on page 10110 ff., with a tandem aza Payne/hydroamination reaction of a precursor alkynyl aziridinol being used to create a pyrrolidinone core with functionalities in place for further elaboration. A carbene generated from a vinyl bromide leads to intramolecular C−H insertion at a sterically demanding carbon center to forge the required C−C bond.

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