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Electrostatic Complementarity Drives Amyloid/Nucleic Acid Co‐Assembly
Author(s) -
Rha Allisandra K.,
Das Dibyendu,
Taran Olga,
Ke Yonggang,
Mehta Anil K.,
Lynn David G.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201907661
Subject(s) - nucleic acid , complementarity (molecular biology) , amyloid (mycology) , amyloid fibril , chemistry , biochemistry , biophysics , amyloid β , biology , disease , genetics , medicine , inorganic chemistry , pathology
Proteinaceous plaques associated with neurodegenerative diseases contain many biopolymers including the polyanions glycosaminoglycans and nucleic acids. Polyanion‐induced amyloid fibrillation has been implicated in disease etiology, but structural models for amyloid/nucleic acid co‐assemblies remain limited. Here we constrain nucleic acid/peptide interactions with model peptides that exploit electrostatic complementarity and define a novel amyloid/nucleic acid co‐assembly. The structure provides a model for nucleic acid/amyloid co‐assembly as well as insight into the energetic determinants involved in templating amyloid assembly.