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Exploration of a Chiral Cobalt Catalyst for Visible‐Light‐Induced Enantioselective Radical Conjugate Addition
Author(s) -
Zhang Kai,
Lu LiangQiu,
Jia Yue,
Wang Ying,
Lu FuDong,
Pan Fangfang,
Xiao WenJing
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201907478
Subject(s) - enantioselective synthesis , catalysis , conjugate , cobalt , conjugated system , visible spectrum , radical , chemistry , octahedron , photocatalysis , alkyl , photochemistry , combinatorial chemistry , organic chemistry , materials science , ion , polymer , mathematical analysis , mathematics , optoelectronics
Chiral catalysts tolerating photochemical reactions are in great demand for the vast development of visible‐light‐induced asymmetric synthesis. Now, chiral octahedral complexes based on earth‐abundant metal and chiral N 4 ligands are reported. One well‐defined chiral Co II ‐complex is shown to be an efficient catalyst in the visible‐light‐induced conjugated addition of enones by alkyl and acyl radicals, providing synthetically valued chiral ketones and 1,4‐dicarbonyls in 47–>99 % yields with up to 97:3 e.r.