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Direct Synthesis of Carbamoyl Fluorides by CO 2 Deoxyfluorination
Author(s) -
Onida Killian,
Tlili Anis
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201907354
Subject(s) - reagent , fluoride , reaction conditions , combinatorial chemistry , chemistry , process (computing) , organic chemistry , computer science , catalysis , inorganic chemistry , programming language
Herein, a new concept for the direct synthesis of carbamoyl fluoride derivatives is disclosed. The developed method makes use of CO 2 as an inexpensive and abundant C 1 source; a variety of amines were successfully converted in the presence of a deoxyfluorinating reagent. The corresponding products were often obtained in excellent yields under mild reaction conditions (1 atm and room temperature). The reaction was easily scaled up, demonstrating the efficiency of the developed process.