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Membrane‐Anchoring Photosensitizer with Aggregation‐Induced Emission Characteristics for Combating Multidrug‐Resistant Bacteria
Author(s) -
Chen Huan,
Li Shengliang,
Wu Min,
Huang Zhongming,
Lee ChunSing,
Liu Bin
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201907343
Subject(s) - photosensitizer , singlet oxygen , escherichia coli , bacteria , photodynamic therapy , staphylococcus aureus , chemistry , membrane , antimicrobial , multiple drug resistance , antibacterial activity , aggregation induced emission , fluorescence , biophysics , microbiology and biotechnology , combinatorial chemistry , photochemistry , oxygen , biology , biochemistry , antibiotics , organic chemistry , quantum mechanics , gene , genetics , physics
Traditional photosensitizers (PSs) show reduced singlet oxygen ( 1 O 2 ) production and quenched fluorescence upon aggregation in aqueous media, which greatly affect their efficiency in photodynamic therapy (PDT). Meanwhile, non‐targeting PSs generally yield low efficiency in antibacterial performance due to their short lifetimes and small effective working radii. Herein, a water‐dispersible membrane anchor (TBD‐anchor) PS with aggregation‐induced emission is designed and synthesized to generate 1 O 2 on the bacterial membrane. TBD‐anchor showed efficient antibacterial performance towards both Gram‐negative ( Escherichia coli ) and Gram‐positive bacteria ( Staphylococcus aureus ). Over 99.8 % killing efficiency was obtained for methicillin‐resistant S. aureus (MRSA) when they were exposed to 0.8 μ m of TBD‐anchor at a low white light dose (25 mW cm −2 ) for 10 minutes. TBD‐anchor thus shows great promise as an effective antimicrobial agent to combat the menace of multidrug‐resistant bacteria.