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Back Cover: Unidirectional Presentation of Membrane Proteins in Nanoparticle‐Supported Liposomes (Angew. Chem. Int. Ed. 29/2019)
Author(s) -
Chen Wen,
Cai Yongfei,
Fu Qingshan,
Chen Bing,
Guo Junling,
Chou James J.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201907302
Subject(s) - liposome , cover (algebra) , nanoparticle , membrane , membrane protein , immune system , nanotechnology , biophysics , substrate (aquarium) , chemistry , materials science , biology , biochemistry , engineering , immunology , mechanical engineering , ecology
Presentation of membrane proteins to host immune systems in a conformation‐specific manner is a major challenge in vaccine or antibody development. In their Communication on page 9866 ff., J. Guo, J. J. Chou, et al. developed a method to address this challenge. They used a functionalized nanoparticle as a substrate to guide the formation of proteoliposome that can unidirectionally present many copies of membrane proteins.