Premium
Dual Photoredox/Nickel‐Catalyzed Three‐Component Carbofunctionalization of Alkenes
Author(s) -
GarcíaDomínguez Andrés,
Mondal Rahul,
Nevado Cristina
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201906692
Subject(s) - alkene , alkyl , catalysis , reagent , nickel , sulfonyl , chemistry , photoredox catalysis , combinatorial chemistry , stoichiometry , photochemistry , functional group , double bond , organic chemistry , photocatalysis , polymer
Abstract The potential of merging photoredox and nickel catalysis to perform multicomponent alkene difunctionalizations under visible‐light irradiation is demonstrated here. Secondary and tertiary alkyl groups, as well as sulfonyl moieties can be added to the terminal position of the double bond with simultaneous arylation of the internal carbon atom in a single step under mild reaction conditions. The process, devoid of stoichiometric additives, benefits from the use of bench‐stable and easy‐to‐handle reagents, is operationally simple, and tolerates a wide variety of functional groups.