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Organic Semiconducting Pro‐nanostimulants for Near‐Infrared Photoactivatable Cancer Immunotherapy
Author(s) -
Li Jingchao,
Cui Dong,
Huang Jiaguo,
He Shasha,
Yang Zebin,
Zhang Yan,
Luo Yu,
Pu Kanyi
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201906288
Subject(s) - immunostimulant , chemistry , immunotherapy , cancer research , immune system , cancer immunotherapy , antigen , tumor microenvironment , singlet oxygen , conjugated system , cancer , immunology , medicine , polymer , oxygen , organic chemistry
In this study, an organic semiconducting pro‐nanostimulant (OSPS) with a near‐infrared (NIR) photoactivatable immunotherapeutic action for synergetic cancer therapy is presented. OSPS comprises a semiconducting polymer nanoparticle (SPN) core and an immunostimulant conjugated through a singlet oxygen ( 1 O 2 ) cleavable linkers. Upon NIR laser irradiation, OSPS generates both heat and 1 O 2 to exert combinational phototherapy not only to ablate tumors but also to produce tumor‐associated antigens. More importantly, NIR irradiation triggers the cleavage of 1 O 2 ‐cleavable linkers, triggering the remote release of the immunostimulants from OSPS to modulate the immunosuppressive tumor microenvironment. Thus, the released tumor‐associated antigens in conjunction with activated immunostimulants induce a synergistic antitumor immune response after OSPS‐mediated phototherapy, resulting in the inhibited growth of both primary/distant tumors and lung metastasis in a mouse xenograft model, which is not observed for sole phototherapy.