Premium
Back Cover: Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF 4 )‐Derived Connective Hubs for Bioconjugation to DNA and Proteins (Angew. Chem. Int. Ed. 24/2019)
Author(s) -
Liu Feng,
Wang Hua,
Li Suhua,
Bare Grant A. L.,
Chen Xuemin,
Wang Chu,
Moses John E.,
Wu Peng,
Sharpless K. Barry
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201906154
Subject(s) - bioconjugation , chemistry , biocompatible material , click chemistry , dna , combinatorial chemistry , cover (algebra) , nanotechnology , biochemistry , materials science , medicine , mechanical engineering , biomedical engineering , engineering
SuFEx goes biology New biocompatible SOF 4 ‐based SuFEx reactions operating at low concentration in aqueous solution under mild pH and temperature conditions provide access to asymmetric and trisubstituted products at the sulfur(VI) center with versatile S−N and S−O connectivity. The SuFEx bioconjugation of iminosulfur oxydifluorides to either BSA protein or to single‐stranded DNA is demonstrated. Details can be found in the Communication by K. B. Sharpless et al. on page 8029.