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Metal‐Modified Nucleic Acids: Metal‐Mediated Base Pairs, Triples, and Tetrads
Author(s) -
Naskar Shuvankar,
Guha Rweetuparna,
Müller Jens
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201905913
Subject(s) - nucleic acid , base pair , metal , chemistry , base metal , pyrimidine , nucleoside , combinatorial chemistry , base (topology) , nucleic acid structure , metal ions in aqueous solution , purine , stereochemistry , dna , materials science , biochemistry , rna , mathematics , organic chemistry , enzyme , mathematical analysis , welding , metallurgy , gene
Abstract The incorporation of metal ions into nucleic acids by means of metal‐mediated base pairs represents a promising and prominent strategy for the site‐specific decoration of these self‐assembling supramolecules with metal‐based functionality. Over the past 20 years, numerous nucleoside surrogates have been introduced in this respect, broadening the metal scope by providing perfectly tailored metal‐binding sites. More recently, artificial nucleosides derived from natural purine or pyrimidine bases have moved into the focus of Ag I ‐mediated base pairing, due to their expected compatibility with regular Watson–Crick base pairs. This minireview summarizes these advances in metal‐mediated base pairing but also includes further recent progress in the field. Moreover, it addresses other aspects of metal‐modified nucleic acids, highlighting an expansion of the concept to metal‐mediated base triples (in triple helices and three‐way junctions) and metal‐mediated base tetrads (in quadruplexes). For all types of metal‐modified nucleic acids, proposed or accomplished applications are briefly mentioned, too.