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Luminescent, Oxygen‐Supplying, Hemoglobin‐Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy
Author(s) -
Jiang Linye,
Bai Haotian,
Liu Libing,
Lv Fengting,
Ren Xueqin,
Wang Shu
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201905884
Subject(s) - conjugated system , chemiluminescence , luminol , photodynamic therapy , photochemistry , nanoparticle , polymer , chemistry , reactive oxygen species , oxygen , luminescence , hemoglobin , nanotechnology , materials science , organic chemistry , optoelectronics , biochemistry
Abstract Photodynamic therapy (PDT) is a promising method for cancer treatment. Two parameters that influence the efficacy of PDT are the light source and oxygen supply. Herein, we prepared a system for PDT using hemoglobin (Hb)‐linked conjugated polymer nanoparticles (CPNs), which can luminesce and supply oxygen. Hb catalyzes the activation of luminol, the conjugated polymer poly[2‐methoxy‐5‐(2‐ethylhexyloxy)‐1,4‐phenylenevinylene] (MEH–PPV) nanoparticles can absorb the chemiluminescence of luminol through chemiluminescence resonance energy transfer (CRET) and then sensitize the oxygen supplied by Hb to produce reactive oxygen species that kill cancer cells. This system could be used for the controlled release of an anticancer prodrug. The system does not need an external light source and circumvents the insufficient level molecular oxygen under hypoxia. This work provides a proof‐of‐concept to explore smart and multifunctional nanoplatforms for phototherapy.