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Argentination of Fluoroform: Preparation of a Stable AgCF 3 Solution with Diverse Reactivities
Author(s) -
Xiang JiaXiang,
Ouyang Yao,
Xu XiuHua,
Qing FengLing
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201905782
Subject(s) - trifluoromethylation , reactivity (psychology) , chemistry , scalability , product (mathematics) , organic chemistry , mathematics , computer science , medicine , alkyl , alternative medicine , pathology , trifluoromethyl , geometry , database
The transformation of a large‐volume industrial by‐product and stable greenhouse gas fluoroform (HCF 3 ) to useful products has recently received significant attention. Now, a simple and scalable preparation of AgCF 3 by treatment of HCF 3 with t ‐BuOK and AgOAc is disclosed. The reactivity of the HCF 3 ‐derived AgCF 3 has been demonstrated by hydrotrifluoromethylation of alkenes and C−H trifluoromethylation of (hetero)arenes. This work not only provides a new avenue for the utilization of HCF 3 , but also presents a reliable and easy‐to‐execute synthesis of the relatively stable AgCF 3 solution.