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Feedstock Reagents in Metal‐Catalyzed Carbonyl Reductive Coupling: Minimizing Preactivation for Efficiency in Target‐Oriented Synthesis
Author(s) -
Doerksen Rosalie S.,
Meyer Cole C.,
Krische Michael J.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201905532
Subject(s) - reagent , catalysis , chemistry , raw material , combinatorial chemistry , organic chemistry , coupling reaction
Use of abundant feedstock pronucleophiles in catalytic carbonyl reductive coupling enhances efficiency in target‐oriented synthesis. For such reactions, equally inexpensive reductants are desired or, ideally, corresponding hydrogen autotransfer processes may be enacted wherein alcohols serve dually as reductant and carbonyl proelectrophile. As described in this Minireview, these concepts allow reactions that traditionally require preformed organometallic reagents to be conducted catalytically in a byproduct‐free manner from inexpensive π‐unsaturated precursors.