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Evolution of Nucleic‐Acid‐Based Constitutional Dynamic Networks Revealing Adaptive and Emergent Functions
Author(s) -
Yue Liang,
Wulf Verena,
Wang Shan,
Willner Itamar
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201905235
Subject(s) - deoxyribozyme , nucleic acid , chemistry , cleavage (geology) , nanotechnology , dna , biochemistry , materials science , fracture (geology) , composite material
The evolution of networks is a fundamental unresolved issue in developing the area of systems chemistry. We introduce a versatile rewiring mechanism that leads to the emergence of nucleic‐acid‐based constitutional dynamic networks (CDNs). A two‐component constituent AA′ functionalized with a Mg 2+ ‐ion‐dependent DNAzyme activator unit forms a complex with an intact hairpin H BB′ composed of B and B′ sequences. Cleavage of H BB′ leads to the two‐component constituent BB′, and its rewiring with AA′ yields CDN X composed of the equilibrated constituents AA′, AB′, BA′, and BB′. In analogy, subjecting AA′ to an intact hairpin H CC′ leads to the formation of CDN Y consisting of AA′, AC′, CA′, and CC′. Subjecting AA′ to the mixture of H BB′ and H CC′ evolves the [3×3] CDN Z, composed of nine constituents, thus demonstrating hierarchical adaptive properties. Furthermore, the DNAzyme units associated with the constituents are applied to tailor emerging catalytic functions from the different CDNs.