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Synthesis of Hypervalent Iodine(III) Reagents Containing a Transferable (Diarylmethylene)amino Group and Their Use in the Oxidative Amination of Silyl Ketene Acetals
Author(s) -
Kiyokawa Kensuke,
Okumatsu Daichi,
Minakata Satoshi
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201904971
Subject(s) - hypervalent molecule , amination , ketene , silylation , chemistry , reagent , imine , benzophenone , iodine , organic chemistry , combinatorial chemistry , hydrolysis , catalysis
The preparation of some hypervalent iodine reagents containing a transferable amino group derived from benzophenone imine derivatives is reported. The reagents can be readily prepared and stored as a bench‐stable solid, and were successfully used in the transition‐metal‐free oxidative amination of silyl ketene acetals to afford the corresponding α‐amino esters, the benzophenone imine moieties of which could be easily hydrolyzed, thereby leading to the formation of primary amines.