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α‐Arylation of Carbonyl Compounds through Oxidative C−C Bond Activation
Author(s) -
Li Jing,
Bauer Adriano,
Di Mauro Giovanni,
Maulide Nuno
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201904899
Subject(s) - chemistry , oxidative phosphorylation , aryl , carbonyl group , functional group , oxidative addition , combinatorial chemistry , transformation (genetics) , photochemistry , stereochemistry , catalysis , organic chemistry , biochemistry , alkyl , gene , polymer
A synthetically useful approach for the direct α‐arylation of carbonyl compounds through a novel oxidative C−C bond activation is reported. This mechanistically unusual process relies on a 1,2‐aryl shift and results in all‐carbon quaternary centers. The transformation displays broad functional‐group tolerance and can in principle also be applied as an asymmetric variant.