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Demethylenation of Cyclopropanes via Photoinduced Guest‐to‐Host Electron Transfer in an M 6 L 4 Cage
Author(s) -
Cullen William,
Takezawa Hiroki,
Fujita Makoto
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201904752
Subject(s) - cage , electron transfer , chemistry , electron , host (biology) , crystallography , photoinduced electron transfer , photochemistry , materials science , physics , biology , engineering , quantum mechanics , ecology , structural engineering
Unusual demethylenation reactions of cyclopropanes under UV‐light irradiation were found within a cavity of a photoactive coordination cage. The reaction proceeded via a guest‐to‐host electron transfer owing to the highly electron‐deficient nature of the cage. The reactions were highly chemoselective and enabled late‐stage derivatization of a steroid molecule, which led to a totally new un‐natural steroid.