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Molecular Design of a New Diboronic Acid for the Electrohydrodynamic Monitoring of Glucose
Author(s) -
Wang Bing,
Chou KuangHua,
Queenan Bridget N.,
Pennathur Sumita,
Bazan Guillermo C.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201904595
Subject(s) - maltose , chemistry , lactose , fructose , galactose , monosaccharide , selectivity , sucrose , biochemistry , catalysis
A new dicationic diboronic acid structure, DBA2+ , was designed to exhibit good affinity ( K d ≈1 m m ) and selectivity toward glucose. Binding of DBA2+ to glucose changes the p K a of DBA2+ from 9.4 to 6.3, enabling opportunities for detection of glucose at physiological pH. Proton release from DBA2+ is firmly related to glucose concentrations within the physiologically relevant range (0–30 m m ), as verified by conductimetric monitoring. Negligible interference from other sugars (for example, maltose, fructose, sucrose, lactose, and galactose) was observed. These results demonstrate the potential of DBA2+ for selective, quantitative glucose sensing. The nonenzymatic strategy based on electrohydrodynamic effects may enable the development of stable, accurate, and continuous glucose monitoring platforms.